Selected pictures of HIV-1 reverse transcriptase (RT)

by Kalyan Das

Different conformations of RT when bound to different substrate/inhibitors

Movement of p66-thumb subdomain with the binding of dsDNA or a nonnucleoside RT (inhibitor (NNRTI) to HIV-1 RT

Crystal structure of HIV-1 RT/dsDNA complex

Locations of the important active sites in HIV-1 RT/dsDNA structure

Locations of nucleoside RT inhibitor (NRTI) mutation sites in HIV-1 RT/dsDNA structure

Commonly occurring drug-resistance sites in HIV-1 RT

Binding modes of NNRTIs to HIV-1 RT

Comparison of structures of wild-type and Tyr181Cys mutant RT TIBO complexes
 

---- This page will soon be updated with more RT pictures. ----