The Michael M. Shen Lab - Research Interests

The Shen laboratory investigates the molecular mechanisms involved in pattern formation and organogenesis during vertebrate development. In particular, the lab is examining (i) pattern formation during pre-gastrulation and gastrulation stages of embryogenesis, (ii) regulation of transforming growth factor-beta (TGFβ) signaling in early mouse embryogenesis, and (iii) prostate development and cancer in mouse model systems. These studies primarily utilize experimental approaches involving genetically-engineered mice, but also employ cell culture and biochemical approaches to investigate molecular mechanisms.