Abate-Shen, C., and Shen, M. M. (2008). FGF signaling in prostate tumorigenesis - new insights into epithelial-stromal interactions. Cancer Cell 12, 495-497.

Oki, S., Hashimoto, R., Okui, Y., Shen, M. M., Mekada, E., Otani, H., Saijoh, Y., and Hamada, H. (2007). Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development 134, 3893-3904.

Shen, M. M., and Abate-Shen, C. (2007). Pten inactiviation and the emergence of androgen-independent prostate cancer. Cancer Res. 67, 6535-6538.

Shen, M. M. (2007). Nodal signaling: developmental roles and regulation. Development 134, 1023-1034.

Lin, Y., Liu, G., Zhang, Y., Hu, Y. P., Yu, K., Lin, C., McKeehan, K., Xuan, J. W., Ornitz, D. M., Shen, M. M., Greenberg, N., McKeehan, W. L., and Wang, F. (2007). Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquistion of strict androgen dependency for adult tissue homeostasis. Development 134, 723-734.

Gao, H., Ouyang, X., Banach-Petrosky, W. A., Gerald, W. L., Shen, M. M., and Abate-Shen, C. (2006). Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc. Natl. Acad. Sci. USA 103, 14477-14482.

Gao, H., Ouyang, X., Banach-Petrosky, W. A., Shen, M. M., and Abate-Shen, C. (2006). Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice. Cancer Res. 66, 7929-7933.

Shiratori, H., Yashiro, K., Shen, M. M., and Hamada, H. (2006). Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development 133, 3015-3025.

Chen, C., Ware, S. M., Sato, A., Houston-Hawkins, D. E., Habas, R., Matzuk, M. M., Shen, M. M., and Brown, C. W. (2006). The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development 133, 319-329.

Chu, J., Ding, J., Jeays-Ward, K., Price, S. M., Placzek, M., and Shen, M. M. (2005). Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development 132, 5539-5551.

Sonntag, K. C., Simantov, R., Bjorklund, L., Cooper, O., Pruszak, J., Kowalke, F., Gimartin, J., Ding, J., Hu, Y.-P., Shen, M. M., and Isacson, O. (2005). Context-dependent neuronal differentiation and germ layer induction of Smad4 (-/-) and Cripto (-/-) embryonic stem cells. Mol. Cell Neurosci. 28, 417-429.

Saijoh, Y., Oki, S., Tanaka, C., Nakamura, T., Adachi, H., Yan, Y.-T., Shen, M. M., and Hamada, H. (2005). Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. Dev. Dyn. 232, 1031-1036. (Epub ahead of print).

Abate-Shen, C., and Shen, M. M. (2005). An unusual gene dosage effect of p27^kip1 in a mouse model of prostate cancer. Cell Cycle 4. (Epub ahead of print).

Gao, H., Ouyang, X., Banach-Petrosky, W., Borowsky, A. D., Lin, Y., Kim, M., Lee, H., Shih, W. J., Cardiff, R. D., Shen, M. M., and Abate-Shen, C. (2005). A critical role for p27^kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc. Natl. Acad. Sci. USA 101, 17204-17209.

Sleat, D. E., Wiseman, J. A., El-Banna, M., Kim, K. H., Mao, Q., Price, S., Macauley, S. L., Sidman, R. L., Shen, M. M., Zhao, Q., Passini, M. A., Davidson, B. L., Stewart, G. R., and Lobel, P. (2004). A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activitiy and progressive neurodegeneration. J. Neurosci. 24, 9117-9126.

Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M., and Xiang, M. (2004). Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43, 795-807.

Sleat, D. E., Wiseman, J. A., El-Banna, M., Price, S. M., Verot, L., Shen, M. M., Tint, G. S., Vanier, M. T., Walkley, S. U., and Lobel, P. (2004). Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc. Natl. Acad. Sci. USA 101, 5886-91.

Chen, C., and Shen, M. M. (2004). Two modes by which Lefty proteins inhibit nodal signaling. Current Biology 14, 618-624.

Berman, D. M., Desai, N., Wang, X., Karhadkar, S. S., Reynon, M., Abate-Shen, C., Beachy, P. A., and Shen, M. M. (2004). Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev. Biol. 267, 387-398.

Shen, M. M., and Abate-Shen, C. (2003). Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev. Dyn. 228, 767-778.

Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M. M., Behringer, R. R., Shen, M. M., and Birchmeier, W. (2003). Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130, 6283-6294.

Shen, M. M. (2003). Decrypting the role of Cripto in tumorigenesis. J. Clin. Invest. 112, 500-502.

Patten, I., Kulesa, P., Shen, M. M., Fraser, S., and Placzek. M. (2003). Distinct modes of floor plate induction in the chick embryo. Development 130, 4809-4821.

Abate-Shen, C., Banach-Petrosky, W. A., Sun, X., Economides, K. D., Desai, N., Gregg, J. P., Borowsky, A. D., Cardiff, R. D., and Shen, M. M. (2003). Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res. 63, 3886-3890.

Dai, X., Lercher, L. D., Clinton, P. M., Du, Y. Livingston, D. L., Viera, C., Yang, L., Shen, M. M., and Dreyfus, C. F. (2003). The trophic role of oligodendrocytes in the basal forebrain. J. Neurosci. 23, 5846-5853.

Iratni, R., Yan, Y.-T., Chen, C., Ding, J., Zhang, Y., Price, S. M., Reinberg, D., and Shen, M. M. (2002). Inhibition of excess Nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science 298, 1996-1999.

Yan, Y.-T., Liu, J.-J., Luo, Y., E, C., Haltiwanger, R. S., Abate-Shen, C., and Shen, M. M. (2002). Dual roles of Cripto as a ligand and co-receptor in the Nodal signaling pathway. Mol. Cell. Biol. 22, 4439-4449.

Kim, M. J., Bhatia-Gaur, R., Banach-Petrosky, W., Desai, N., Wang, Y., Hayward, S. W., Cunha, G. R., Cardiff, R. D., Shen, M. M., and Abate-Shen, C. (2002). Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res. 62, 2999-3004.

Abate-Shen, C., and Shen, M. M. (2002). Mouse models of prostate carcinogenesis. Trends Genet. 18, (5) S1-S5 (online).

Kim, M. J., Cardiff, R. D., Desai, N., Banach-Petrosky, W., Parsons, R., Shen, M. M., and Abate-Shen, C. (2002). Cooperativity of Nkx3.1 and Pten loss-of-function in a mouse model of prostate carcinogenesis. Proc. Natl. Acad. Sci. USA 99, 2884-2889.

Park, J.-H., Walls, J. E., Galvez, J. J., Kim, M. J., Abate-Shen, C., Shen, M. M., and Cardiff, R. D. (2002). Prostatic intraepithelial neoplasia in genetically engineered mice. Am. J. Path. 161, 727-735.

Li, S., Price, S. M., Cahill, H., Ryugo, D. K., Shen, M. M., and Xiang, M. (2002). Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129, 3523-3532.

Kimura, C., Shen, M. M., Takeda, N., Aizawa, S., and Matsuo, I. (2001). Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev. Biol. 235, 12-32.

Hu, G., Lee, H., Price, S. M., Shen, M. M., and Abate-Shen, C. (2001). Msx homeobox genes inhibit differentiation through up-regulation of Cyclin D1. Development 128, 2373-2384.

Shen, M. M. (2001). Identification of differentially expressed genes in mouse development using differential display and in situ hybridization. Methods 24, 15-27.

Abate-Shen, C., and Shen, M. M. (2000). Molecular genetics of prostate cancer. Genes Dev. 14, 2410-2434.

Shen, M. M., and Schier, A. F. (2000). The EGF-CFC gene family in vertebrate development. Trends Genet. 16, 303-309.

Bamford, R. N., Roessler, E., Burdine, R. D., Saplakoglu, U., de la Cruz, J., Splitt, M., Towbin, J., Bowers, P., Marino, B., Schier, A. F., Shen, M. M., Muenke, M., and Casey, B. (2000). Loss-of-function mutations in the EGF-CFC gene Cfc1 are associated with human left-right laterality defects. Nature Genet. 26, 365-369.

Schier, A. F., and Shen, M. M. (2000). Nodal signaling in vertebrate development. Nature 403, 385-389.

Mudgett, J. S., Ding, J., Guh-Siesel, L., Chartrain, N. A., Yang, L., Gopal, S., and Shen, M. M. (2000). Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA 97, 10454-10459.

Yan, Y.-T., Stein, S. M., Ding, J., Shen, M. M., and Abate-Shen, C. (2000). A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein. Mol. Cell. Biol. 20, 661-671.

Yan, Y.-T., Gritsman, K., Ding, J., Burdine, R. D., Corrales, J. D., Price, S. M., Talbot, W. S., Schier, A. F., and Shen, M. M. (1999). Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 13, 2527-2537.

Bhatia-Gaur, R., Donjacour, A. A., Sciavolino, P. J., Kim, M., Desai, N., Young, P., Norton, C., Gridley, T., Cardiff, R. D., Cunha, G. R., Abate-Shen, C., and Shen, M. M. (1999). Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13, 966-977.

Bendall, A., Ding, J., Hu, G., Shen, M. M., and Abate-Shen, C. (1999). Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors. Development 126, 4965-4976.

Ding, J., Yang, L., Yan, Y.-T., Chen, A., Desai, N., Wynshaw-Boris, A., and Shen, M. M. (1998). Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 395, 702-707.

Yang, L., Zhang, H., Hu, G., Wang, H., Abate-Shen, C., and Shen, M. M. (1998). An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate. J. Neuroscience 18, 8322-8330.

Shen, M. M. (1998). Meeting report - Cell signaling in growth and development. 11th annual CABM symposium, October 1997. BBA Reviews on Cancer 1377, R55-R62.

Raymond, C. S., Shamu, C. E., Shen, M. M., Seifert, K. J., Hirsch, B., Hodgkin, J., and Zarkower, D. (1998). Evidence for evolutionary conservation of sex-determining genes. Nature 391, 691-695.

Shen, M. M., Wang, H., and Leder, P. (1997). A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development 124, 429-442.

Sciavolino, P. J., Abrams, E. W., Yang, L., Austenberg, L. P., Shen, M. M., and Abate-Shen, C. (1997). Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. 209, 127-138.

Zhang, H., Hu., G., Wang, H., Sciavolino, P., Iler, N., Shen, M. M., and Abate-Shen, C. (1997). Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol. Cell. Biol. 17, 2920-2932.

Catron, K. M., Wang, H., Hu, G., Shen, M. M., and Abate-Shen, C. (1996). Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy. Mech. Dev. 55, 185-199.

Deng, C.-X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D. M., and Leder, P. (1994). Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8, 3045-3057.

Shen, M. M., Skoda, R. C., Cardiff, R. D., Campos-Torres, J., Leder, P., and Ornitz, D. M. (1994). Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 13, 1375-1385.

Leder, A., Kuo, A., Shen, M. M., and Leder, P. (1992). In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors. Development 116, 1041-1049.

Shen, M. M., and Leder, P. (1992). Leukemia inhibitory factor is expressed by the pre-implantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc. Natl. Acad. Sci. USA 89, 8240-8244.

Miller, D. M., Shen, M. M., Shamu, C. E., Burglin, T. R., Ruvkun, G., Dubois, M. L., Ghee, M., and Wilson, L. (1992). C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature 355, 841-845.

Hodgkin, J., Chisholm, A. D., and Shen, M. M. (1989). Major sex-determining genes and the control of sexual dimorphism in Caenorhabditis elegans. Genome 31, 625-637.

Shen, M. M., and Hodgkin, J. (1988). mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans. Cell 54, 1019-1031.

Shen, M. M., Raleigh, E. A., and Kleckner, N. (1987). Physical analysis of Tn10- and IS10-promoted transpositions and rearrangements. Genetics 116, 359-369.

Hodgkin, J., Doniach, T., and Shen, M. (1985). The sex determination pathway in the nematode Caenorhabditis elegans: variations on a theme. Cold Spring Harbor Symp. Quant. Biol. 50, 583-593.

Updated 02/05/08